NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC 50 0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC 50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19 , respectively.
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What are the CAS number, molecular formula and molecular weight?
The CAS Number is 3032452-65-3, the molecular formula is C14H13FN4O, and the molecular weight is 272.28 g/mol.
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