NucPE1 - ≥98% , CAS No.1404091-23-1

CAS: 1404091-23-1 Cat. No.: N647968 分子式: C₂₉H₃₀BNO₅ 分子量: 483.36 PubChem CID: 129626434

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

概要

NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

In Vitro

NucPE1 features two major visible region absorptions (λ abs =468 nm, ε=27,300 M -1 cm -1 ; λ abs =490 nm, ε=26,000 M -1 cm -1 ) and a weak emission (λ em =530 nm, Φ=0.117). Reaction of NucPE1 with H 2 O 2 triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M -1 cm -1 ) with enhanced emission (λ em =530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like C. clegans , where it can respond to subcellular changes in H 2 O 2 fluxes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NucPE1 maintains the ability to selectively target nuclei in vivo . NucPE1 imaging reveals a reduction in nuclear H 2 O 2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

保管条件

Store at 2-8°C,Protected from light,Argon charged

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

• カノニカル・スマイル: B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(C=C2)C4(C5=CC=CC=C5C(=O)O4)C6=C(O3)C=C(C(=C6)C)NCC
• IUPAC Name: 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9'-xanthene]-1-one
• InChIKey: GHPDUBPWQBBRPG-UHFFFAOYSA-N
• INCHI: 1S/C29H30BNO5/c1-7-31-23-16-25-22(14-17(23)2)29(20-11-9-8-10-19(20)26(32)34-29)21-13-12-18(15-24(21)33-25)30-35-27(3,4)28(5,6)36-30/h8-16,31H,7H2,1-6H3
• PubChem CID: 129626434
• 分子量: 483.36

化学的性質と物理的性質

• 溶解度: DMSO : 25 mg/mL (51.72 mM; Need ultrasonic)
• 分子量: 483.400 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 483.222 Da
• Monoisotopic Mass: 483.222 Da
• Topological Polar Surface Area: 66.000 Ų
• Heavy Atom Count: 36
• Formal Charge: 0
• Complexity: 849.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1404091-23-1, the molecular formula is C29H30BNO5, and the molecular weight is 483.36 g/mol. InChIKey GHPDUBPWQBBRPG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.