NVP018 (BC556) is an orally active inhibitor for cyclophilin A with IC 50 of 0.3 and 0.1 nM for cyclophilin A and NS5A- cyclophilin A complex. NVP018 inhibits Bilirubin transporter OATP1B1 and OATP1B3 with IC 50 of 4.31 and 1.75 μM. NVP018 inhibits the replication of HBV (in HepG2), HCV (in Huh-7) and HIV-1 (in HeLa), with IC 50 in nanomolar levels. NVP018 exhibits anti-fibrotic effect by inhibiting the mRNA expression of COL1A1 and LOX.
その他の情報
| CAS | 1401924-49-9 |
|---|---|
| 保管条件 | Store at -20°C |
| 入荷 | Ice chest + Ice pads |
| Product Description | NVP018 (BC556) is an orally active inhibitor for cyclophilin A with IC 50 of 0.3 and 0.1 nM for cyclophilin A and NS5A- cyclophilin A complex. NVP018 inhibits Bilirubin transporter OATP1B1 and OATP1B3 with IC 50 of 4.31 and 1.75 μM. NVP018 inhibits the replication of HBV (in HepG2), HCV (in Huh-7) and HIV-1 (in HeLa), with IC 50 in nanomolar levels. NVP018 exhibits anti-fibrotic effect by inhibiting the mRNA expression of COL1A1 and LOX. |
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