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NXP800 - ≥99% , CAS No.1693734-80-3
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research
In Vitro
NXP800 (example 169) inhibits U20S cells viability (IC 50 =0.056 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of 120% relative to control. Pharmacokinetic AnalysisSpecies Route Dose (mg/kg) T max (h) AUC last (ng·h/mL) Cl tb (mL/min/kg) t 1/2 (h) F (%) AUC u 0-t (h·nM) Free C av 0-24h (nM) Cl u (mL/min/kg) mouse po/iv 5/5 2.0 6000 (7800-4600) (po) 10 (10-9.7) (iv) 4.0 42 (po) 72 3.3 830 (iv) rat po/iv 5/1 6.0 2600 (po) 24 (iv) 3.1 45 (po) 86 3.7 730 (iv) dog po/iv 2.5/0.5 2.0 250 (po) 21 (iv) 1.4 9.1 (po) 35 1.9 150 (iv) MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:HSF1
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 hasxa0thexa0potentialxa0forxa0cancer research.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥99%
Names and Identifiers
| Molecular Weight | 569.63 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (175.55 mM; Need ultrasonic) |
|---|
Solution Calculators
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Customer Reviews
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