ODN 2216 - ≥97% , CAS No.332437-00-0

CAS: 332437-00-0 Cat. No.: O647086 分子量: 6432.00

GRADE & PURITY ≥97%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

概要

ODN 2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β . ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4 + T cells

In Vitro

ODN 2216 (6 μg/mL, 9 days) drives Th1 development of naive CD4 T cells. ODN 2216 (2 μM, 15 h) significantly decreased apoptosis of thymic DC. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Thymic DC, pDC Concentration: 2 μM Incubation Time: 15 h Result: Significantly decreased apoptosis of thymic DC (23.1 ± 0.9%), and naturally induced apoptosis of thymic pDC was not decreased (72.8 ± 2.9%).

In Vivo

ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination modelsMCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:TLR9 IL-12

Specifications

仕様と純度

≥97%

生化学的・生理学的メカニズム

ODNu20042216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODNu20042216 induces high amounts of IFN-α and IFN-β . ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates

保管条件

Store at -20°C,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ACTIVATOR

純度

≥97%

名前と識別子

分子量

6432.00

よくある質問

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 332437-00-0, and the molecular weight is 6432.00 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.