Oglufanide - 10mM in DMSO , CAS No.38101-59-6

CAS: 38101-59-6 Cat. No.: O655662 分子式: C₁₆H₁₉N₃O₅ 分子量: 333.34 PubChem CID: 100094

グレード＆純度 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF) . Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities

In Vitro

Oglufanide (IM862) (1-1000 μg/mL) exhibits dose dependent inhibition of angiogenesis in the chorioallantoic membrane assay with complete inhibition of β-FGF and VEGF-induced angiogenesis. ?\nOglufanide (L-glu-L-trp) (0-1000 μg/mL; 5 days) has no effect on the viability of either the tumor cell lines or HUVECs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oglufanide (L-glu-L-trp) (1-100 mg/kg/day; s.c.; 10 days) has antitumor activity in immunocompetent and immunodeficient mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 immune competent mice, Lewis lung carcinoma (LLC) xenograft; Balb/C athymic mice, M21 human melanoma xenograftDosage: 1, 10, 50 and 100 mg/kg/day Administration: Subcutaneous injection, 10 days Result: Resulted in a dose-dependent inhibition of LLC tumor growth in syngeneic immune competent mice and showed a dose-dependent decrease in tumor volumes of xenografts in Balb/C athymic mice implanted with M21 human melanoma cells.

IC50& Target:VEGFR|HCV|Human Endogenous Metabolite

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF) . Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infecti

保管条件

Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

異性体SMILES

C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N

代替CAS番号

38101-59-6,122933-59-9

PubChem CID

100094

MeSH用語

alpha-glutamyltryptophan;Glu-Trp;L-alpha-glutamyl-L-tryptophan

分子量

333.34