Oleamide - ≥70% , CAS No.301-02-0

CAS: 301-02-0 Cat. No.: O105240 分子式: C₁₈H₃₅NO 分子量: 281.48 Beilstein Registry Number: 2(4)1668 EC番号: 206-103-9

グレード＆純度 ≥70%

Synonyms

9-Octadecenamide, (9Z)- | (9Z)-octadec-9-enamide | Crodamide O | cis-9,10-Octadecenoamide | (Z)-9-OCTADECENAMIDE | Armoslip CP | Oleamide | Oleylamide | Adogen 73 | Crodamide OR | 9-Octadecenamide | Oleic acid amide | Slip-eze | Oleyl amide | (Z)-octadec-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Oleamide is a lipid or a brain fatty acid, that is found in the CSF (cerebrospinal fluid). It is originally obtained from the cerebrospinal fluid of cats, that are sleep-deprived.

仕様

同義語

9-Octadecenamide, (9Z)- | (9Z)-octadec-9-enamide | Crodamide O | cis-9,10-Octadecenoamide | (Z)-9-OCTADECENAMIDE | Armoslip CP | Oleamide | Oleylamide | Adogen 73 | Crodamide OR | 9-Octadecenamide | Oleic acid amide | Slip-eze | Oleyl amide | (Z)-octadec-

仕様と純度

≥70%

生化学的・生理学的メカニズム

Endogenous sleep-inducing lipid. Acts as an agonist at the CB1cannabinoid receptor (EC50= 1.64μM). Also appears to potentiate the actions of 5-HT on 5-HT2Aand2Creceptors, and act via an allosteric regulatory site on 5-HT7receptors.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥70%

名前と識別子

パブケム・シド

488195275

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/488195275

カノニカル・スマイル

CCCCCCCCC=CCCCCCCCC(=O)N

IUPAC Name

(Z)-octadec-9-enamide

InChIKey

FATBGEAMYMYZAF-KTKRTIGZSA-N

INCHI

1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-

異性体SMILES

CCCCCCCC/C=C\CCCCCCCC(=O)N

WGKドイツ

1

RTECS

RG2230000

分子量

281.48

Beilstein

2(4)1668

Reaxy-Rn

8157587

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8157587&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • 分類 Fatty Acyls
      • Subclass Fatty amides

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• 分類: Fatty Acyls
• Subclass: Fatty amides
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty amides
• Alternative Parents: Primary carboxylic acid amides Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty amide - Primary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound
• 説明: This compound belongs to the class of organic compounds known as fatty amides. These are carboxylic acid amide derivatives of fatty acids, that are formed from a fatty acid and an amine.
• External Descriptors: Primary amides

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

HTR7 Tclin 5-hydroxytryptamine receptor 7 (0 Activities)

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ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

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AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

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GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

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CSNK1D Tchem Casein kinase I delta (4546 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)

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CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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U2OS (164939 Activities)

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CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)

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FPR2 Tchem Lipoxin A4 receptor (3472 Activities)

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FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)

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BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

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GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)

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BRPF1 Tchem Peregrin (2217 Activities)

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HEK-293T (167025 Activities)

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Aplnr Apelin receptor (201 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Soat1 Acyl coenzyme A:cholesterol acyltransferase 1 (295 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Faah Anandamide amidohydrolase (3907 Activities)

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Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

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Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 Activities)

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Rattus norvegicus (775804 Activities)

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RAW264.7 (28094 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)

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Gabrp GABA-A receptor; anion channel (5731 Activities)

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SARS-CoV-2 (38078 Activities)

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作用メカニズム

化学的性質と物理的性質

• 溶解度: Solvent:ethanol, Max Conc. mg/mL: 28.15, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 14.07, Max Conc. mM: 50
• 融点（°C）: 65-75°C
• 分子量: 281.500 g/mol
• XLogP3: 6.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 15
• Exact Mass: 281.272 Da
• Monoisotopic Mass: 281.272 Da
• Topological Polar Surface Area: 43.100 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 236.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1