OP-1074 - ≥99% , CAS No.1443752-76-8

CAS: 1443752-76-8 Cat. No.: O650512 分子式: C₂₉H₃₁NO₄ 分子量: 457.56

GRADE & PURITY ≥99%

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

概要

OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2 nM, respectively

In Vitro

OP-1074 (0-100 nM; 24 hours) inhibits  MCF-7 cells  and CAMA-1 cells proliferation with IC50 values of 6.3 and 9.2 nM, respectively. OP-1074 (100 nM; 24 hours) destabilizatizes ERα protein expression in MCF-7 and CAMA-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells, CAMA-1 cells Concentration: 0 nM, 10 nM,100 nM Incubation Time: 24 hours Result: Inhibited breast cancer cell proliferation. Western Blot AnalysisCell Line: MCF-7 cells, CAMA-1 cells Concentration: 100 nM Incubation Time: 24 hours Result: Downregulated ERα protein expression.

Form:Solid

IC50& Target:ERα ERβ

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2u2009nM, respectively.

保管条件

Store at -20°C,Argon charged,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

DEGRADER

純度

≥99%

名前と識別子

分子量

457.56

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (218.55 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1443752-76-8, the molecular formula is C29H31NO4, and the molecular weight is 457.56 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.