オピオルフィン - モリガンド™, ≥95 , Inhibitor of Aminopeptidase N, CAS No.864084-88-8, Inhibitor of Aminopeptidase N

CAS: 864084-88-8 Cat. No.: O346764 分子式: C₂₉H₄₈N₁₂O₈ 分子量: 692.77 PubChem CID: 25195667

グレード＆純度 Moligand™, ≥95%

Synonyms

L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine | CHEBI:177467 | DTXSID901027119 | HY-W345510 | GTPL11538 | Opiorphin | D93123 | (2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopen

Storage

20℃で保存する。

Shipped In

アイスチェスト＋アイスパッド

概要

ヒトの唾液中に分泌される天然の鎮痛剤。オピオルフィンは、エンケファリンを不活性化するエクトペプチダーゼであるヒトNEP（hNEP）とヒトAP-N（hAP-N）に対して二重の阻害力を示す。鎮痛薬として、オピオルフィンはオピエートであるモルヒネの6倍強い。オピオルフィンはラットのシアロルフィンペプチドと密接な関係があり、疼痛知覚の阻害剤であり、内因性の微小およびδオピオイド受容体依存性のエンケファリン作動性経路を増強することによって作用する。ラットの研究では、オピオルフィンは化学物質による炎症と急性の身体的痛みの両方で痛覚を抑制した。いずれの場合も、1mg/kgの投与量で、3～6mg/kgのモルヒネと同じ鎮痛力を示した。

仕様

同義語

L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine | CHEBI:177467 | DTXSID901027119 | HY-W345510 | GTPL11538 | Opiorphin | D93123 | (2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopen

仕様と純度

モリガンド™, ≥95

保管条件

20℃で保存する。

入荷

アイスチェスト＋アイスパッド

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of Aminopeptidase N

純度

≥95%

名前と識別子

カノニカル・スマイル

C1=CC=C(C=C1)CC(C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)N

IUPAC Name

(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid

InChIKey

TWWFCOBVAKAKIT-SXYSDOLCSA-N

INCHI

1S/C29H48N12O8/c30-17(10-11-22(31)43)23(44)38-18(8-4-12-36-28(32)33)24(45)40-20(14-16-6-2-1-3-7-16)25(46)41-21(15-42)26(47)39-19(27(48)49)9-5-13-37-29(34)35/h1-3,6-7,17-21,42H,4-5,8-15,30H2,(H2,31,43)(H,38,44)(H,39,47)(H,40,45)(H,41,46)(H,48,49)(H4,32,33,36)(H4,34,35,37)/t17-,18-,19-,20-,21-/m0/s1

異性体SMILES

C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N

WGKドイツ

3

PubChem CID

25195667

分子量

692.77

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 分類 Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 分類: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Phenylalanine and derivatives Glutamine and derivatives N-acyl-L-alpha-amino acids Serine and derivatives Alpha amino acid amides Amphetamines and derivatives N-acyl amines Secondary carboxylic acid amides Primary carboxylic acid amides Amino acids Guanidines Propargyl-type 1,3-dipolar organic compounds Carboximidamides Carboxylic acids Monocarboxylic acids and derivatives Organopnictogen compounds Primary alcohols Organic oxides Carbonyl compounds Hydrocarbon derivatives Monoalkylamines
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha-oligopeptide - Phenylalanine or derivatives - Glutamine or derivatives - N-acyl-l-alpha-amino acid - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Serine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Monocyclic benzene moiety - Fatty amide - Fatty acyl - N-acyl-amine - Benzenoid - Amino acid or derivatives - Amino acid - Carboxamide group - Guanidine - Primary carboxylic acid amide - Secondary carboxylic acid amide - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Monocarboxylic acid or derivatives - Carboxylic acid - Alcohol - Organopnictogen compound - Hydrocarbon derivative - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organic oxide - Organonitrogen compound - Organooxygen compound - Primary alcohol - Primary amine - Amine - Aromatic homomonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

ANPEP Tchem Aminopeptidase N (0 Activities)

Discover Target: ANPEP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MME Tclin Neprilysin (838 Activities)

Discover Target: MME

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: Soluble in water
• 分子量: 692.800 g/mol
• XLogP3: -7.000
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 23
• Exact Mass: 692.372 Da
• Monoisotopic Mass: 692.372 Da
• Topological Polar Surface Area: 372.000 Ų
• Heavy Atom Count: 49
• Formal Charge: 0
• Complexity: 1170.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

よくある質問

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 864084-88-8, the molecular formula is C29H48N12O8, and the molecular weight is 692.77 g/mol. InChIKey TWWFCOBVAKAKIT-SXYSDOLCSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.