10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells.
Targets
OGT (Cell-free assay) 3 μM(EC50)
In vitro
OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology.
Cell Research(from reference)
Cell lines：HEK293T cells
Concentrations：5 μM, 10 μM, 20 μM
Incubation Time：2 h, 8 h, 16 h, 24 h
| ALogP | 3.175 |
|---|---|
| HBD数 | 2 |
| 回転可能な結合 | 12 |
| パブケム・シド | 528766484 |
|---|---|
| カノニカル・スマイル | CCOC(=O)CN(CC1=CC=CS1)C(=O)C(C2=CC=CC=C2OC)NS(=O)(=O)C3=C(C=C4C(=C3)C=CC(=O)N4)Cl |
| IUPAC Name | ethyl 2-[[(2R)-2-[(7-chloro-2-oxo-1H-quinolin-6-yl)sulfonylamino]-2-(2-methoxyphenyl)acetyl]-(thiophen-2-ylmethyl)amino]acetate |
| InChIKey | STPSLAZMEWZDAJ-AREMUKBSSA-N |
| INCHI | 1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1 |
| PubChem CID | 137319721 |
| 分子量 | 604.09 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | 日付 | 商品 |
|---|---|---|---|
 J2415602 | Certificate of Analysis | Aug 01, 2026 | O422714 |
| DMSO（mg / mL） 最大溶解度 | 100 |
|---|---|
| DMSO（mM） 最大溶解度 | 165.538247612111 |
| 水（mg / mL） 最大溶解度 | ＜1 |
