OSS_128167 (SIRT6-IN-1) is a specificSIRT6inhibitor withIC50values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.

Targets

SIRT6 (Cell-free); SIRT2 (Cell-free); SIRT1 (Cell-free) 89 μM; 751 μM; 1578 μM

In vitro

OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression.

Cell Research(from reference)

Cell lines：BxPC3 cells

Concentrations：100 μM

Incubation Time：0, 2, 6, 18, 24 h

仕様

同義語

SIRT6-IN-1

仕様と純度

≥99%

生化学的・生理学的メカニズム

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

パブケム・シド

504764265

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/504764265

カノニカル・スマイル

C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

IUPAC Name

5-[[3-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid

InChIKey

HTJWLEGCECXGSQ-UHFFFAOYSA-N

INCHI

1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)

異性体SMILES

C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

分子量

366.32

Reaxy-Rn

26990252

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26990252&ln=

ドキュメント

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詳細データ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 分類 Benzene and substituted derivatives
    - Subclass Anilides
      - Level5 Aromatic anilides
        Level6 Benzanilides

Kingdom	Organic compounds
Superclass	Benzenoids
分類	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Aromatic anilides
Direct Parent	Benzanilides
Alternative Parents	2-furanilides Salicylic acids Benzamides Benzoic acids 2-heteroaryl carboxamides Furoic acid and derivatives Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Heteroaromatic compounds Secondary carboxylic acid amides Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organooxygen compounds Organopnictogen compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzanilide - 2-furanilide - Furanilide - Salicylic acid or derivatives - Salicylic acid - Hydroxybenzoic acid - Benzoic acid or derivatives - Benzoic acid - Benzamide - Benzoyl - 2-heteroaryl carboxamide - Furoic acid or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Furan - Heteroaromatic compound - Vinylogous acid - Carboxamide group - Secondary carboxylic acid amide - Monocarboxylic acid or derivatives - Oxacycle - Carboxylic acid - Carboxylic acid derivative - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
説明	This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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レビュー

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Lot Number	Certificate Type	日付	商品
F2214789	Certificate of Analysis	Mar 04, 2025	O414086
F2214790	Certificate of Analysis	Mar 04, 2025	O414086
J2431155	Certificate of Analysis	May 26, 2022	O414086
L2404267	Certificate of Analysis	May 26, 2022	O414086

溶解度	Solubility (25°C) In vitro DMSO: 73 mg/mL (199.27 mM); Water: Insoluble; Ethanol: Insoluble;
分子量	366.300 g/mol
XLogP3	2.700
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	366.085 Da
Monoisotopic Mass	366.085 Da
Topological Polar Surface Area	129.000 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	568.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

OSS_128167 - ≥99% , CAS No.887686-02-4

保管・配送

品質書類

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概要

仕様