Ozagrel - Moligand™, 10mM in DMSO , Thromboxane-A synthase inhibitor, CAS No.82571-53-7, Thromboxane-A synthase inhibitor

CAS: 82571-53-7 Cat. No.: O409274 分子式: C₁₃H₁₂N₂O₂ 分子量: 228.25

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

OKY-046 | (2E)​-3-​[4-​(1H-​imidazol-​1-​ylmethyl)​phenyl]​-2-​propenoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Ozagrel (OKY-046) is a selectivethromboxane A(2) (TXA(2)) synthetaseinhibitor withIC50of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
In vitro

In vivo

Ozagrel prevents oleic acid (OA)-induced thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung of guinea pigs. Ozagrel (3 mg/kg) decreases both the area and volume of the cortical infarction after ischemia-reperfusion of the middle cerebral artery in rat. Ozagrel also has suppressive effects on the neurologic deficits in the microthrombosis rat model. Ozagrel improves the reduced spontaneously locomotor activity and the obstruction of motor coordination in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel suppresses the decrease in specific gravity of the brain tissue induced by the occlusion-reperfusion in the conscious cerebral ischemia-reperfusion SHR model, and recovers the postischemic decrease in cortical PO(2) after middle cerebral artery occlusion-reperfusion in cats. Ozagrel also increases the level of 6-keto-PGF(1alpha), a metabolite of prostaglandin I(2) (PGI(2)), in the brain tissue after cerebral ischemia-reperfusion, and the administration of PGI(2) improves the reduced spontaneous locomotor activity in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel administered intravenously 30 min before oleic acid injection prevents the decrease in Pao(2) and pulmonary vascular hyper-permeability in guinea-pigs. Ozagrel also prevents increases in lactate dehydrogenase activity, a measure of lung cell injury, TXB(2) and its weight ratio to 6-keto prostaglandin F(1alpha) in bronchoalveolar lavage fluid in guinea-pigs.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

OKY-046 | (2E)​-3-​[4-​(1H-​imidazol-​1-​ylmethyl)​phenyl]​-2-​propenoic acid

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Ozagrel (OKY-046) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Thromboxane-A synthase inhibitor

製品の性質

• ALogP: 1.6

名前と識別子

• 異性体SMILES: C1=CC(=CC=C1CN2C=CN=C2)/C=C/C(=O)O
• 分子量: 228.25
• Reaxy-Rn: 5539138
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5539138&ln=

関連ターゲット（人間）

TBXAS1 Tchem Thromboxane-A synthase (8 Activities)

Discover Target: TBXAS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 56 mg/mL (197.0 mM)
• 融点（°C）: 223-224°C

参考文献

1. Min Li, Fen Liu, Yong-Ri Jin, Xiao-Zhong Wang, Qian Wu, Ying Liu, Xu-Wen Li.  (2016)  Five New Triterpenoid Saponins from the Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity.  PLANTA MEDICA,      [PMID:27676700] [10.1055/s-0042-117554]

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 82571-53-7, the molecular formula is C13H12N2O2, and the molecular weight is 228.25 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.