P11149 - ≥99% , CAS No.164724-79-2

CAS: 164724-79-2 Cat. No.: P647520 分子式: C₂₇H₃₄ClNO₄ 分子量: 472.02

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

概要

P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE . P11149 exhibits an IC 50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer's disease

In Vivo

P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG . P11149 exhibits greater s.c. bioavailability than p.o. . Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats . P11149 exhibits T 1/2 (el) of 2.4 h and C max of 585 ng/mL in rat plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 1.3 μM (rat BChE/AChE)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE . P11149 exhibits an IC 50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and sa

保管条件

Store at 2-8°C,Desiccated

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 472.02

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (211.86 mM; Need ultrasonic)