Pancuronium dibromide - Moligand™, 10mM in DMSO , Antagonist of nicotinic acetylcholine receptor α1 subunit, CAS No.15500-66-0, Antagonist of nicotinic acetylcholine receptor α1 subunit

CAS: 15500-66-0 Cat. No.: P409215 分子式: C₃₅H₆₀Br₂N₂O₄ 分子量: 732.67 Beilstein Registry Number: 4226892 EC番号: 239-532-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,​1'-​[(2β,​3α,​5α,​16β,​17β)​-​3,​17-​bis(acetyloxy)​androstane-​2,​16-​diyl]​bis[1-​methyl-​piperidinium,dibromide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Pancuronium dibromide Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.
In vitro

Pancuronium\xa0results in open\xa0channel\xa0block\xa0of embryonic-type\xa0nicotinic\xa0acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in\xa0competitive\xa0block\xa0of embryonic-type\xa0nicotinic acetylcholine receptor channels. Pancuronium\xa0increases heart rate,\xa0vecuronium\xa0and\xa0rocuronium\xa0produces positive inotropic\xa0effects, and\xa0vecuronium shortens refractoriness in isolated rat atria.\xa0 Pancuronium (0.5 mM) induces a complete\xa0fade\xa0of the\xa0tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat.\xa0Pancuronium\xa0decreases the amplitude and increases the\xa0tetanic\xa0rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.

In vivo

Pancuronium\xa0decreases tidal volume (VT) and minute ventilation (VE) in high dose\xa0dogs by 82%. Pancuronium\xa0decreases tidal volume (VT) and minute ventilation (VE) in low dose\xa0dogs by 40% and 55%. Pancuronium limits\xa0cerebral\xa0hyperemia during prolonged\xa0seizures\xa0by attenuating increases in\xa0blood\xa0pressure as a result of elimination of skeletal muscle activity in newborn pigs. Pancuronium\xa0results in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM \xa0in\xa0tracheal\xa0smooth muscle\xa0strips from\xa0guinea-pigs.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

1,​1'-​[(2β,​3α,​5α,​16β,​17β)​-​3,​17-​bis(acetyloxy)​androstane-​2,​16-​diyl]​bis[1-​methyl-​piperidinium,dibromide

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Pancuronium dibromide is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ANTAGONIST

作用メカニズム

Antagonist of nicotinic acetylcholine receptor α1 subunit

名前と識別子

• 異性体SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
• WGKドイツ: 3
• RTECS: TN4930000
• UN番号: UN 2811
• 包装グループ: III
• 分子量: 732.67
• Beilstein: 4226892

関連ターゲット（人間）

CHRNA1 Tclin Acetylcholine receptor subunit alpha (0 Activities)

Discover Target: CHRNA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

参考文献

1. Haifeng Yao, Yahui Zhang, Yongping Dong, Mingfu Ye.  (2023)  Inhibiting effect of graphdiyne on Ru(bpy)32+ ECL and its application in drug detection based on the host–guest interaction of cucurbit[8]uril.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.jelechem.2023.117868]