PF-6683324 - ≥99% , CAS No.1799788-94-5

CAS: 1799788-94-5 Cat. No.: P648737 分子式: C₂₄H₂₃F₄N₅O₄ 分子量: 521.46 EC番号: 110-753-8 PubChem CID: 118189484

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC 50 s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA , TrkB and TrkC , respectively Anti-hyperalgesic effect

In Vitro

PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC 50 >5 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:TrkA 1.9 nM (IC 50 , in cell-based assays) TrkB 2.6 nM (IC 50 , in cell-based assays) TrkC 1.1 nM (IC 50 , in cell-based assays)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC 50 s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA , TrkB and TrkC , respectively. Anti-hyperalgesic effect.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• カノニカル・スマイル: CN1C=C(N=C1)C2=CC(=C(N=C2)OC3CCN(CC3F)C(=O)CC4=CC=C(C=C4)OC(F)(F)F)C(=O)N
• IUPAC Name: 2-[(3S,4R)-3-fluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]piperidin-4-yl]oxy-5-(1-methylimidazol-4-yl)pyridine-3-carboxamide
• InChIKey: XJIIVPVOGYFVME-AZUAARDMSA-N
• INCHI: 1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m0/s1
• 異性体SMILES: CN1C=C(N=C1)C2=CC(=C(N=C2)O[C@@H]3CCN(C[C@@H]3F)C(=O)CC4=CC=C(C=C4)OC(F)(F)F)C(=O)N
• PubChem CID: 118189484
• 分子量: 521.46

関連ターゲット（人間）

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (1 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NTRK1 Tclin Nerve growth factor receptor Trk-A (7922 Activities)

Discover Target: NTRK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : ≥ 100 mg/mL (191.77 mM)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1799788-94-5, the molecular formula is C24H23F4N5O4, and the molecular weight is 521.46 g/mol. InChIKey XJIIVPVOGYFVME-AZUAARDMSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.