PF-9363 - Moligand™, 10mM in DMSO , CAS No.2569009-58-9

CAS: 2569009-58-9 Cat. No.: P656210 分子式: C₂₀H₂₀N₄O₆S 分子量: 444.46 PubChem CID: 155411202

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer

In Vitro

PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker. PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC 50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: ZR75-1, T47D and MCF7 cells Concentration: 0~1 μM Incubation Time: 1 day Result: Down-regulated the expression of H3K23Ac biomarker.

In Vivo

PF-9363 shows strong anti-tumor activity in patient-derived xenograft models . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:KAT6A/KAT6B

Specifications

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

名前と識別子

• PubChem CID: 155411202
• 分子量: 444.46