PFK15 - Moligand™, 10mM in DMSO , Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3, CAS No.4382-63-2, Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

CAS: 4382-63-2 Cat. No.: P407887 分子式: C₁₇H₁₂N₂O 分子量: 260.29 EC番号: 809-326-5 PubChem CID: 25142799

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
In vitro

PFK15 produces potent growth inhibition in a series of cancer cells. In Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells, PFK15 also reduces F26BP, glucose uptake, and intracellular ATP level.

In vivo

In vivo, PFK15 has adequate pharmacokinetic properties. PFK15 (25 mg/kg i.p.) suppresses the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three human xenograft models of cancer in athymic mice, PFK15 also yields antitumor effects that are comparable to approved chemotherapeutic agents.
Cell Data

cell lines：

Concentrations：~30 μM

Incubation Time：48 hours

Powder Purity:≥99%

Specifications

同義語

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

名前と識別子

• 異性体SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
• WGKドイツ: 3
• 代替CAS番号: 4382-63-2
• PubChem CID: 25142799
• MeSH用語: 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;PFK15
• 分子量: 260.29

関連ターゲット（人間）

PFKFB3 Tchem 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (1 Activities)

Discover Target: PFKFB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)