PLX5622 - Moligand™, 10mM in DMSO , Inhibitor of KIT proto-oncogene; receptor tyrosine kinase, CAS No.1303420-67-8, Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

CAS: 1303420-67-8 Cat. No.: P409126 分子式: C₂₁H₁₉F₂N₅O 分子量: 395.41 PubChem CID: 52936034

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

3-​Pyridinemethanamine, 5-​fluoro-​N-​[6-​fluoro-​5-​[(5-​methyl-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl)​methyl]​-​2-​pyridinyl]​-​2-​methoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

PLX5622 PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.
In vitro

In vivo

In vivo PLX5622 demonstrates desirable PK properties in mice, rats, dogs, and monkeys, with a brain penetrance of ~20%. PLX5622 has low systemic clearance, moderate volume of distribution, and favorable oral bioavailability (F > 30%) in all four species. PLX5622 is a useful compound for investigating microglial dynamics. It allows for the sustained and specific elimination of microglia, preceding and during pathology development of Alzheimer’s disease (AD). Long-term PLX5622-mediated microglial depletion is highly robust, sustainable, and specific to the microglial compartment.
Cell Data

cell lines：Ba/F3 cells expressing JAK2V617F (Ba/F3-EpoR-V617F) and MPLW515L (Ba/F3-W515L) mutants.

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

同義語

3-​Pyridinemethanamine, 5-​fluoro-​N-​[6-​fluoro-​5-​[(5-​methyl-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl)​methyl]​-​2-​pyridinyl]​-​2-​methoxy-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing\u2009>\u200920-fold selectivity over KIT and FLT3.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

製品の性質

• ALogP: 4.577
• HBD数: 2
• 回転可能な結合: 6

名前と識別子

• 異性体SMILES: CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1
• 代替CAS番号: 1303420-67-8
• PubChem CID: 52936034
• MeSH用語: PLX5622
• 分子量: 395.41

関連ターゲット（人間）

KIT Tclin Mast/stem cell growth factor receptor Kit (0 Activities)

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• DMSO（mg / mL） 最大溶解度: 79
• DMSO（mM） 最大溶解度: 199.792620318151
• 水（mg / mL） 最大溶解度: ＜1

参考文献

1. Hanqi Wang, Yijun Chen, Junna Chang, Zhen Liu, Yang Yu.  (2026)  FPR2 deficiency alleviates LPS-induced depressive-like behaviors in mice by suppressing the microglial CSF1/NLRP3 inflammasome pathway.  Journal of Neuroinflammation,      [PMID:42458515] [10.1186/s12974-026-03963-4]

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1303420-67-8, the molecular formula is C21H19F2N5O, and the molecular weight is 395.41 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.