Podofilox - Moligand™, 10 mM in DMSO , CAS No.518-28-5

CAS: 518-28-5 Cat. No.: P1498094 分子式: C₂₂H₂₂O₈ 分子量: 414.41 Beilstein Registry Number: 99163 EC番号: 208-250-4

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

Specifications

仕様と純度

Moligand™, 10 mM in DMSO

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

製品の性質

• ALogP: 2

名前と識別子

• 異性体SMILES: COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O
• WGKドイツ: 3
• RTECS: LV2500000
• UN番号: 3462
• 分子量: 414.41
• Beilstein: 99163
• Reaxy-Rn: 366516
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=366516&ln=

化学的性質と物理的性質

• 比旋光度［α］: -129° (C=1,CHCl3)
• 融点（°C）: 178-184°C

参考文献

1. Lidong Cheng, Zhiqing Mo, Qiongzhi Zhang, Man Yang, Xianglin Liao, Liyu Qiu, Shizhong Wang, Xixiang Yang, Xiaogang Hu.  (2023)  Development of hydroxypropyl cellulose and graphene oxide modified molecularly imprinted polymers for separation and enrichment of podophyllotoxin.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:37857153] [10.1016/j.chroma.2023.464452]

2. Mei Dong, Cheng Zhao, Yongfang Huang, Ke Zheng, Guanhu Bao, Fenglin Hu, Fan Peng, Mingjun Chen, Zengzhi Li, Ruili Lu.  (2023)  Metabolites analysis and new bioactive compounds from the medicine food homology product of Cordyceps chanhua on artificial media.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:37801798] [10.1016/j.jpba.2023.115749]

3. Simin Deng, Yuan Xu, Binbin Gao, Tingting Yu, Lun Kuang, Bo’ang Han, Shaolun Feng, Haodong Chi, Qing Cao, Shen Yue, Chen Liu.  (2023)  Anemarrhenasaponin I suppresses ovarian cancer progression via inhibition of SHH signaling pathway.  Oncologie,  25  (3): (233-243).  [PMID:] [10.1515/oncologie-2022-1001]

4. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang.  (2022)  Poly(methacrylate citric acid) as a Dual Functional Carrier for Tumor Therapy.  Pharmaceutics,  14  (9): (1765).  [PMID:36145512] [10.3390/pharmaceutics14091765]

5. Huixia Feng, Guilin Chen, Yongli Zhang, Mingquan Guo.  (2022)  Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2.  Journal of Inflammation Research,      [PMID:35996684] [10.2147/JIR.S371830]

6. Yan Zhao, Danyao Li, Yun Han, Haohao Wang, Rui Du, Zhaowei Yan.  (2022)  The ester derivatives obtained by C-ring modification of podophyllotoxin-induced apoptosis and inhibited proliferation in Hemangioma Endothelial Cells via downregulation of PI3K/Akt signaling pathway.  Chemical Biology & Drug Design,  99  (6): (828-838).  [PMID:35184389] [10.1111/cbdd.14034]

7. Bingfeng Liang, Dangxia Zhou.  (2021)  ROS-Activated homodimeric podophyllotoxin nanomedicine with self-accelerating drug release for efficient cancer eradication.  DRUG DELIVERY,      [PMID:34747277] [10.1080/10717544.2021.1995076]

8. Feng Huixia, Chen Guilin, Zhang Yongli, Guo Mingquan.  (2021)  Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration.  Frontiers in Pharmacology,      [PMID:34759823] [10.3389/fphar.2021.749189]

9. Meitao Duan, Ahmed Mahal, Ban Mohammed, Yongyan Zhu, Huaming Tao, Shaoyu Mai, Maysoon Al-Haideri, Quanhong Zhu.  (2021)  Synthesis and antitumor activity of new tetrahydrocurcumin derivatives via click reaction.  NATURAL PRODUCT RESEARCH,      [PMID:34030539] [10.1080/14786419.2021.1931181]

10. Jiali Sun, Qi Wei, Na Shen, Zhaohui Tang, Xuesi Chen.  (2020)  Predicting the Loading Capability of mPEG-PDLLA to Hydrophobic Drugs Using Solubility Parameters†.  CHINESE JOURNAL OF CHEMISTRY,  38  (7): (690-696).  [PMID:] [10.1002/cjoc.202000078]

11. Chao Chen, Yong Yu, Xiaoli Wang, Ping Shi, Yibing Wang, Ping Wang.  (2016)  Manipulation of pH-Sensitive interactions between podophyllotoxin-chitosan for enhanced controlled drug release.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:27867056] [10.1016/j.ijbiomac.2016.11.053]

12. Yuee Tian, Shiyue Ma, Yibo Liu, Yan Li, Genqiang Chen, Zhiping Che.  (2024)  Synthesis of Novel 4-Acyloxy-2′-Bromo-6′-Chloropodophyllotoxin Derivatives Displaying Significant Insecticidal Activity Against Mythimna Separata.  CHEMISTRY & BIODIVERSITY,  21  (7): (e202400929).  [PMID:38661022] [10.1002/cbdv.202400929]

13. Li-jun Yang, Shuang Zhao, Sheng-xia Hu, Xin-yue Li, Xiao-hui Zhang, Le-han Wang, Ling Tang.  (2026)  Immunomodulatory and suppressive effects of dual-function micelle targeting FSHR in ovarian cancer therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2026.108233]

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 518-28-5, the molecular formula is C22H22O8, and the molecular weight is 414.41 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.