Pomalidomide-PEG₂-Alkyne - ≥95% , CAS No.P463546

CAS: P463546 Cat. No.: P463546 分子式: C₂₁H₂₁N₃O₇ 分子量: 427.41

GRADE & PURITY ≥95%

Synonyms

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3-(2-(prop-2-yn-1-yloxy)ethoxy)propanamide | Crosslinker–E3 Ligase ligand conjugate | Template for synthesis of targeted protein degrader

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

概要

Description

Protein degrader builiding block Pomalidomide-PEG2-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

同義語

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3-(2-(prop-2-yn-1-yloxy)ethoxy)propanamide | Crosslinker–E3 Ligase ligand conjugate | Template for synthesis of targeted protein degrader

仕様と純度

≥95%

保管条件

Protected from light,Store at -20°C,Argon charged

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥95%

名前と識別子

• 分子量: 427.41

化学的性質と物理的性質

• 感度: Moisture sensitive；Light sensitive