Pomalidomide-PEG₆-Alkyne

Cat. No.: P487817

Synonyms

Protein degrader building block for PROTAC research, Crosslinker–E3 Ligase ligand conjugate, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13,16,19-hexaoxadocos-21-ynamide, Template for synthesis of targeted protein degrader

Storage

Store at 2-8°C

Shipped In

Wet ice

概要

Description

Protein degrader builiding block Pomalidomide-PEG6-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

仕様

同義語

Protein degrader building block for PROTAC research, Crosslinker–E3 Ligase ligand conjugate, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13,16,19-hexaoxadocos-21-ynamide, Template for synthesis of targeted protein degrader

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

保管条件

Store at 2-8°C

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。