Pomalidomide-PEG₆-CO₂H - ≥98% , CAS No.2225148-49-0

CAS: 2225148-49-0 Cat. No.: P486908 分子式: C₂₈H₃₉N₃O₁₂ 分子量: 609.62 PubChem CID: 139034004

GRADE & PURITY ≥98%

Synonyms

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

概要

Description

Protein degrader builiding block Pomalidomide-PEG6-CO2H enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

同義語

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

仕様と純度

≥98%

保管条件

Store at -20°C,Argon charged

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

パブケム・シド

504773551

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/504773551

カノニカル・スマイル

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCOCCC(=O)O

IUPAC Name

3-[2-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

InChIKey

NBDBXIANAMQQQU-UHFFFAOYSA-N

INCHI

1S/C28H39N3O12/c32-23-5-4-22(26(35)30-23)31-27(36)20-2-1-3-21(25(20)28(31)37)29-7-9-39-11-13-41-15-17-43-19-18-42-16-14-40-12-10-38-8-6-24(33)34/h1-3,22,29H,4-19H2,(H,33,34)(H,30,32,35)

PubChem CID

139034004

分子量

609.62

化学的性質と物理的性質

• 感度: Moisture sensitive
• 引火点（°F）: Not applicable
• 引火点（°C）: Not applicable