PQ 401 - Moligand™, 10mM in DMSO , Inhibitor of Insulin-like growth factor I receptor, CAS No.196868-63-0, Inhibitor of Insulin-like growth factor I receptor

CAS: 196868-63-0 Cat. No.: P408859 分子式: C₁₈H₁₆ClN₃O₂ 分子量: 341.79 EC番号: 633-729-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

PQ 401 PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
In vitro

PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.

In vivo

PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.
Cell Data

cell lines：

Concentrations：~50 μM

Incubation Time：3 days

Powder Purity:≥99%

Specifications

同義語

N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of Insulin-like growth factor I receptor

名前と識別子

異性体SMILES

CC1=NC2=CC=CC=C2C(=C1)NC(=O)NC3=C(C=CC(=C3)Cl)OC

WGKドイツ

3

分子量

341.79

Reaxy-Rn

14012784

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14012784&ln=

関連ターゲット（人間）

IGF1R Tclin Insulin-like growth factor 1 receptor (1 Activities)

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 融点（°C）: 190 °C(dec.)

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 196868-63-0, the molecular formula is C18H16ClN3O2, and the molecular weight is 341.79 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.