PROTAC HPK1 Degrader-3 , CAS No.P1436403

CAS: P1436403 Cat. No.: P1436403 分子式: C₄₃H₄₂N₈O₅ 分子量: 750.84

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

PROTAC PD-L1 degrader-2 (compound C3) is an orally effective PROTAC targeting HPK1 (DC50=21.26 nM). HPK1 is a negative regulator of T cell receptors, which can lead to T cell dysfunction after abnormal activation. PROTAC PD-L1 degrader-2 can inhibit SLP76 and NF-κB signaling pathways and inhibit MAPK signal transduction, and has anticancer activity and immune activation. PROTAC PD-L1 degrader-2 has a certain oral bioavailability and can be combined with PD-L1 antibody therapy to achieve a tumor growth inhibition rate of 65.58%. PROTAC PD-L1 degrader-2 is composed of E3 ligase ligand Thalidomide , PROTAC linker tert-Butyl 3-oxoazetidine-1-carboxylate , and target protein ligand HPK1-IN-51 ; the activity control of the target protein ligand can be HPK1 ligand 1.

仕様

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

分子量

750.84