PSB 1114 - Moligand™, ≥98%(HPLC) , Agonist of P2Y 2 receptor, CAS No.1657025-60-9, Agonist of P2Y 2 receptor

CAS: 1657025-60-9 Cat. No.: P288132 分子式: C₁₀H₁₁F₂N₂Na₄O₁₃P₃S 分子量: 622.14 PubChem CID: 52952605

グレード＆純度 Moligand™, ≥98%(HPLC)

Synonyms

4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

仕様

同義語

4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt

仕様と純度

Moligand™, ≥98%(HPLC)

生化学的・生理学的メカニズム

Potent, selective P2Y2agonist (EC50= 0.134μM). Displays >60-fold selectivity versus P2Y4and P2Y6receptors.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

AGONIST

作用メカニズム

Agonist of P2Y 2 receptor

純度

≥98%(HPLC)

名前と識別子

カノニカル・スマイル

C1=CN(C(=O)NC1=S)C2C(C(C(O2)COP(=O)(O)OP(=O)(C(F)(F)P(=O)(O)O)O)O)O

IUPAC Name

[[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]-difluoromethyl]phosphonic acid

InChIKey

DFGBPSGNGNHNQM-XVFCMESISA-N

INCHI

1S/C10H15F2N2O13P3S/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(15)7(16)8(26-4)14-2-1-5(31)13-9(14)17/h1-2,4,6-8,15-16H,3H2,(H,21,22)(H,23,24)(H,13,17,31)(H2,18,19,20)/t4-,6-,7-,8-/m1/s1

異性体SMILES

C1=CN(C(=O)NC1=S)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(C(F)(F)P(=O)(O)O)O)O)O

PubChem CID

52952605

分子量

622.14

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • 分類 Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Monosaccharides
          • Level6 Pentoses
            • Level7 Pentose phosphates

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• 分類: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Monosaccharides - Pentoses
• Direct Parent: Pentose phosphates
• Alternative Parents: Glycosylamines Monosaccharide phosphates Bisphosphonates Pyrimidones Pyrimidinethiones Monoalkyl phosphates Hydropyrimidines Thiolactams Heteroaromatic compounds Oxolanes Organic phosphonic acids Ureas Secondary alcohols 1,2-diols Oxacyclic compounds Azacyclic compounds Organic oxides Hydrocarbon derivatives Alkyl fluorides Organofluorides Organonitrogen compounds Organophosphorus compounds Organosulfur compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pentose phosphate - Pentose-5-phosphate - Glycosyl compound - N-glycosyl compound - Monosaccharide phosphate - Bisphosphonate - Monoalkyl phosphate - Pyrimidone - Pyrimidinethione - Hydropyrimidine - Organic phosphoric acid derivative - Alkyl phosphate - Phosphoric acid ester - Pyrimidine - Heteroaromatic compound - Organophosphonic acid - Organophosphonic acid derivative - Oxolane - Thiolactam - Secondary alcohol - Urea - 1,2-diol - Organoheterocyclic compound - Oxacycle - Azacycle - Alcohol - Organohalogen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Alkyl halide - Organosulfur compound - Alkyl fluoride - Organophosphorus compound - Organofluoride - Aromatic heteromonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

P2RY2 Tclin P2Y purinoceptor 2 (1 Activities)

Discover Target: P2RY2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RY6 Tchem Pyrimidinergic receptor P2Y6 (717 Activities)

Discover Target: P2RY6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P2RY4 Tchem Pyrimidinergic receptor P2Y4 (598 Activities)

Discover Target: P2RY4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P2RY2 Tclin Purinergic receptor P2Y2 (1109 Activities)

Discover Target: P2RY2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: Soluble in water (supplied pre-dissolved at a concentration of 10mM)