PX-478 2HCl - Moligand™, ≥98% , CAS No.685898-44-6
在庫あり
SKU
P413792
HIF Inhibitors
Information
PX-478 2HCl PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.
Targets
HIF-1α
In vitro
PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells.
In vivo
In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues.
その他の情報
| CAS | 685898-44-6 |
|---|---|
| 同義語 | A867013 | PX 478 [WHO-DD] | Q27289565 | s7612 | CCG-268582 | PX 478 | AKOS030231369 | AS-76128 | DTXSID00218688 | SCHEMBL18548830 | AC2217 | BDBM50231387 | L-Phenylalanine, 4-(bis(2-chloroethyl)oxidoamino)-, dihydrochloride | A14319 | PX478 | PX-478 | HY- |
| 仕様と純度 | Moligand™, ≥98% |
| 保管条件 | Store at -20°C,Argon charged |
| 入荷 | Ice chest + Ice pads |
| Product Description | Information PX-478 2HCl PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1. Targets HIF-1α In vitro PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells. In vivo In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues. |
| パブケム・シド | 488197315 |
| パブケム・シド・ウル | https://pubchem.ncbi.nlm.nih.gov/substance/488197315 |
| 溶解度 | Solubility (25°C) In vitro DMSO: 79 mg/mL (200.44 mM); Water: 79 mg/mL (200.44 mM); Ethanol: 20 mg/mL (50.74 mM); |
| 感度 | Moisture sensitive |
| PubChem CID | 11234794 |
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PX-478 2HCl開始 $145.90
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