QM31 - 10mM in DMSO , CAS No.937735-00-7

CAS: 937735-00-7 Cat. No.: Q655526 分子式: C₃₉H₃₈Cl₄N₄O₄ 分子量: 768.56 PubChem CID: 16739770

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC 50 =7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.

In Vitro

SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC 50 of 5 μM in HeLa S100 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1 . QM31 inhibits the formation of the apoptosome (IC 50 =7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprote

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

異性体SMILES

C1C(N(C(=O)CN(C1=O)CCC2=C(C=C(C=C2)Cl)Cl)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)N(CCC5=C(C=C(C=C5)Cl)Cl)CC(=O)N

PubChem CID

16739770

分子量

768.56