≥98% ベースライン干渉を最小限に抑える必要がある、感度の高いクロマトグラフィーおよび分析ワークフロー向け。
Store at -20°C Ice chest + Ice pads に出荷。正確な仕様については、ロット固有の COA をご確認ください。
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クロマトグラフィー、有機合成、クロスカップリング反応に関する 0 件の査読済み論文で引用されています。
Information
R-IMPP R-IMPP is an inhibitor of PCSK9 secretion, half maximal inhibitory concentration [IC50] = 4.8 μM.
Targets
PCSK9
In vitro
R-IMPP promotes uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but instead causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is discovered that exhibited weak PCSK9 anti-secretagogue activity (half maximal inhibitory concentration [IC50] = 4.8 μM), but does not affect intracellular ATP levels in the recombinant CHO-K1 cells, a measure of cytotoxicity, nor decrease secretion of a control protein, secreted alkaline phosphatase, a measure of relative selectivity. The inhibitory response of R-IMPP is stereospecific.
Cell Research(from reference)
Cell lines：Huh7 cells
Concentrations：10, 30 μM
Incubation Time：24 h
危険性、取扱い、保管、および規制遵守を網羅した包括的な文書。
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 日付 | 商品 |
|---|---|---|---|
 I2205328 | Certificate of Analysis | Jun 09, 2025 | R414007 |
| I2205329 | Certificate of Analysis | Jun 09, 2025 | R414007 |
| I2205330 | Certificate of Analysis | Jun 09, 2025 | R414007 |
| I2205331 | Certificate of Analysis | Jun 09, 2025 | R414007 |
| 溶解度 | Solubility (25°C) In vitro DMSO: 77 mg/mL (197.69 mM); Ethanol: 77 mg/mL (197.69 mM); Water: 7 mg/mL (17.97 mM); |
|---|---|
| DMSO（mg / mL） 最大溶解度 | 77 |
| DMSO（mM） 最大溶解度 | 197.6944209 |
| 水（mg / mL） 最大溶解度 | 7 |
| 水（mM） 最大溶解度 | 17.97222008 |
| 分子量 | 389.500 g/mol |
| XLogP3 | 3.800 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 389.21 Da |
| Monoisotopic Mass | 389.21 Da |
| Topological Polar Surface Area | 54.500 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 520.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
