RB-3 - ≥99% , CAS No.2396639-11-3

CAS: 2396639-11-3 Cat. No.: R647132 分子式: C₂₄H₂₀ClN₃O₂ 分子量: 417.89

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

概要

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f , with a K d of 2.8 μM

In Vitro

RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples. RB-3 inhibits H2A ubiquitination with an IC 50 of 1.6 μM. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: TEX cells. Concentration: 6, 12, 25 μM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPα-p42 protein levels.

Form:Solid

IC50& Target:Kd: 2.8 μM (RING1B-BMI1f)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f , with a K d of 2.8 μM.

保管条件

Store at 2-8°C,Protected from light,Desiccated

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

カノニカル・スマイル

O=C(C1=C(C2=C3C=CNC3=CC=C2Cl)C(C(C)C)=C(C4=C5C=CNC5=CC=C4)N1)O

分子量

417.89

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (239.30 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2396639-11-3, the molecular formula is C24H20ClN3O2, and the molecular weight is 417.89 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.