RC-3095 TFA - ≥98% , CAS No.1217463-61-0

CAS: 1217463-61-0 Cat. No.: R648024 分子式: C₅₈H₈₀F₃N₁₅O₁₁ 分子量: 1220.34

GRADE & PURITY ≥98%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

RC-3095 TFA is a selective bombesin / gastrin releasing peptide receptor ( GRPR ) antagonist RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

In Vivo

RC-3095 impairs aversive but not recognition memory in Wistar male rats . RC-3095 (0.3 mg/kg or 1 mg/kg; S.C.) shows anti-inflammatory effects in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA). Arthritic mice treated with RC-3095 show a significant reduction in the concentrations of IL-17, IL-1 , and TNF, and showed a diminished expression of GRPR. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA modelDosage: 1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies Administration: Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies Result: Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA; Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model.

Form:Solid

IC50& Target:Bombesin receptor,GRPR

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

RC-3095 TFA is a selective bombesin / gastrin releasing peptide receptor ( GRPR ) antagonist. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice.

保管条件

Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

• 分子量: 1220.34

化学的性質と物理的性質

• 溶解度: H2O : 50 mg/mL (40.97 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1217463-61-0, the molecular formula is C58H80F3N15O11, and the molecular weight is 1220.34 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.