Rosiptor - Moligand™, 10 mM in DMSO , CAS No.782487-28-9

CAS: 782487-28-9 Cat. No.: R1494221 分子式: C₂₀H₃₅NO₂ 分子量: 321.5 PubChem CID: 76965484

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro .

Specifications

仕様と純度

Moligand™, 10 mM in DMSO

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ACTIVATOR

製品の性質

• ALogP: 3

名前と識別子

• 異性体SMILES: C[C@@]1(CC[C@@H](C[C@@H]1CO)O)[C@H]2CC[C@]3([C@H]([C@@H]2CN)CCC3=C)C
• PubChem CID: 76965484
• 分子量: 321.5

参考文献

1. Li Gao, Junsheng Zhang, Tingting Yang, Ling Jiang, Xueqi Liu, Sheng Wang, Xian Wang, Yuebo Huang, Huaying Wang, Mengya Zhang, Tingting Gong, Lijuan Ma, Chao Li, Chaoyong He, Xiao-ming Meng, Yonggui Wu.  (2023)  STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.  MOLECULAR THERAPY,      [PMID:37533255] [10.1016/j.ymthe.2023.07.026]

2. Fangyuan Chen, Qingmei Liu, Lei Ma, Cuishi Yan, Haiman Zhang, Zhi Zhou, Wei Yi.  (2024)  Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:39705161] [10.1021/acs.jmedchem.4c02803]

3. Zheng Xiao, Peng Luo, Guoli Li, Huifang Tan, Chen Zhou, Dong Zeng, Yinyin Chen, Ying Li.  (2025)  HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41390419] [10.1186/s12951-025-03927-5]