SAE-14 - 10mM in DMSO , CAS No.1241280-25-0

CAS: 1241280-25-0 Cat. No.: S655693 Molecular Weight: 364.36

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC 50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC 50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice

In Vitro

SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC 50 value below 50 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: The human leukemia (HL)-60 cells Concentration: 5×of the antagonist Incubation Time: 15 min Result: Had GPR183-specific (IC 50 : 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.

In Vivo

SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male and female ICR mice Dosage: 2.9 µM Administration: intrathecal (i.th.) injections; 2.9 µM; once Result: Reversed CCI-induced mechanical allodynia in a time-dependent manner.

IC50& Target:IC50: 28.5 nM (GPR183)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC 50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC 50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Molecular Weight: 364.36