SB 706504 - Moligand™, ≥98% , CAS No.911110-38-8

CAS: 911110-38-8 Cat. No.: S287825 分子式: C₂₄H₁₉F₃N₈O 分子量: 492.46

GRADE & PURITY Moligand™, ≥98%

Synonyms

N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

概要

SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD).

Specifications

同義語

N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine

仕様と純度

Moligand™, ≥98%

生化学的・生理学的メカニズム

p38 MAPK inhibitor. Inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs). Also inhibits LPS-induced protein expression of IL-6, IL-10, TNFαandγ-induci

保管条件

Store at -20°C,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

パブケム・シド

528767040

カノニカル・スマイル

N=C(NC#N)NCCNC1=NC(C4=C(C)C=C(F)C=C4)=C(C=CC(N2C3=C(F)C=CC=C3F)=O)C2=N1

InChIKey

ZQFBVJBAWLZLOM-UHFFFAOYSA-N

異性体SMILES

CC1=C(C=CC(=C1)F)C2=C3C=CC(=O)N(C3=NC(=N2)NCCN=C(N)NC#N)C4=C(C=CC=C4F)F

分子量

492.46

Reaxy-Rn

51295675

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=51295675&ln=

化学的性質と物理的性質

• 溶解度: Solvent:DMSO, Max Conc. mg/mL: 49.25, Max Conc. mM: 100