SB505124 - Moligand™, 10mM in DMSO , Inhibitor of transforming growth factor beta receptor 1, CAS No.694433-59-5, Inhibitor of transforming growth factor beta receptor 1

CAS: 694433-59-5 Cat. No.: S408748 分子式: C₂₀H₂₁N₃O₂ 分子量: 335.4 PubChem CID: 9858940

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

SB505124 is a selective inhibitor ofTGFβRforALK4,ALK5withIC50of 129 nM and 47 nM in cell-free assays, respectively, also inhibitsALK7, but does not inhibit ALK1, 2, 3, or 6.
In vitro

SB505124 is identified as a reversible ATP competitive and selective ALK inhibitor of ALK4 and ALK5. SB505124 shows no toxicity to renal epithelial A498 cells at concentrations up to 100 μM for 48 hours, and blocks TGF-β–induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. In human umbilical vein endothelial cells (HUVEC), SB505124 (500 nM) blocks the changes of TGF-β1 on F-actin assembly and prevents ROS production induced by TGF-β. By inhibiting TGF-beta1 signaling, SB505124 leads to decreased deferoxamine (DFO)-induced neurogenesis. A recent study shows that SB505124 suppresses the migration and invasion of breast cancer MCF-7-M5 cells.

In vivo

In a rabbit GFS model, SB505124 decreased the intraocular pressure (IOP) levels and reduces subconjunctival cell infiltration and scarring at the surgical site in the GFS. In tacrolimus (TAC)-treated mice and FK12EC KO mice, SB505124 prevents the activation of endothelial TGF-β receptors and induction of renal arteriolar hyalinosis.
Cell Data

cell lines：

Concentrations：0-10 μM

Incubation Time：48 hours

Powder Purity:≥98%

Specifications

同義語

2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of transforming growth factor beta receptor 1

名前と識別子

• 異性体SMILES: CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4
• PubChem CID: 9858940
• 分子量: 335.4

関連ターゲット（人間）

TGFBR1 Tchem TGF-beta receptor type-1 (1 Activities)

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 48 mg/mL (201.46 mM); Ethanol: 25 mg/mL (104.92 mM); Water: Insoluble
• 融点（°C）: 168 °C

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 694433-59-5, the molecular formula is C20H21N3O2, and the molecular weight is 335.4 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.