Name: SD-208 - Moligand™, 10mM in DMSO , Inhibitor of transforming growth factor beta receptor 1, CAS No.627536-09-8, Inhibitor of transforming growth factor beta receptor 1
SKU: S425185
Availability: InStock

SD-208 - Moligand™, 10mM in DMSO , Inhibitor of transforming growth factor beta receptor 1, CAS No.627536-09-8, Inhibitor of transforming growth factor beta receptor 1

CAS: 627536-09-8 Cat. No.: S425185 分子式: C₁₇H₁₀ClFN₆ 分子量: 352.75 EC番号: 636-373-7 PubChem CID: 10316032

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SD-208 - Moligand™, 10mM in DMSO CAS No(627536-09-8) by Aladdin Scientific

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注文可能

GRADE & PURITY Moligand™ ? 10mM in DMSO

Synonyms

2-(5-chloro-2-fluorophenyl)-4-(4-pyridylamino)pteridine | BCP02214 | FT-0700345 | HMS3604B06 | 1608481-61-3 | 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine | AKOS024457517 | NCGC00165898-01 | A833974 | WLN: 1U2R BQ CO1 | s7624 | SCHEMBL411646

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要 Specifications 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビュー

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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.
A TGF-β signaling blocker

Specifications

同義語

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Potent, orally active ATP-competitive transforming growth factor-βreceptor 1 (TGF-βRI) inhibitor (IC50= 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor act

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of transforming growth factor beta receptor 1

名前と識別子

パブケム・シド	528767076
カノニカル・スマイル	C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
IUPAC Name	2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
InChIKey	BERLXWPRSBJFHO-UHFFFAOYSA-N
INCHI	1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
異性体SMILES	C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
WGKドイツ	3
PubChem CID	10316032
分子量	352.75

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 分類 Pteridines and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
分類	Pteridines and derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Pteridines and derivatives
Alternative Parents	Fluorobenzenes Chlorobenzenes Aminopyrimidines and derivatives Aminopyridines and derivatives Pyrazines Imidolactams Aryl fluorides Aryl chlorides Heteroaromatic compounds Azacyclic compounds Organofluorides Organochlorides Hydrocarbon derivatives Amines
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pteridine - Aminopyridine - Aminopyrimidine - Chlorobenzene - Fluorobenzene - Halobenzene - Aryl chloride - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Imidolactam - Benzenoid - Pyrazine - Pyridine - Pyrimidine - Heteroaromatic compound - Azacycle - Amine - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
説明	This compound belongs to the class of organic compounds known as pteridines and derivatives. These are polycyclic aromatic compounds containing a pteridine moiety, which consists of a pyrimidine fused to a pyrazine ring to form pyrimido(4,5-b)pyrazine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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レビュー

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屈折率	1.72
沸点（°C）	460.41° C at 760 mmHg
融点（°C）	214.79°C
分子量	352.800 g/mol
XLogP3	3.000
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	352.064 Da
Monoisotopic Mass	352.064 Da
Topological Polar Surface Area	76.500 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	437.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1