SDMA - Moligand™, 10mM in DMSO , CAS No.30344-00-4

CAS: 30344-00-4 Cat. No.: S423136 分子式: C₈H₁₈N₄O₂ 分子量: 202.25

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(S)-2-Amino-5-((bis(methylamino)methylene)amino)pentanoicacid | N(G1),N(G2)-Dimethylarginine | N(omega),N'(omega)-dimethyl-L-arginine | N,N'-Dimethylarginine | (S)-2-Amino-5-((bis(methylamino)methylene)amino)pentanoic acid | N5-((methylamino)(methylimino)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

SMDA (symmetric dimethylarginine) is a methylated form of arginine found within all nucleated cells that is released into circulation after proteolysis, then excreted through the kidneys, and correlates well with GFR (glomerular filtration rate) in people, dogs, and cats.

Specifications

同義語

(S)-2-Amino-5-((bis(methylamino)methylene)amino)pentanoicacid | N(G1),N(G2)-Dimethylarginine | N(omega),N'(omega)-dimethyl-L-arginine | N,N'-Dimethylarginine | (S)-2-Amino-5-((bis(methylamino)methylene)amino)pentanoic acid | N5-((methylamino)(methylimino)

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

SDMA (Symmetric dimethylamine) is an endogenous inhibitor of nitric oxide (NO) synthase activity.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

製品の性質

• ALogP: -3.419
• hba_count: 2
• HBD数: 3
• 回転可能な結合: 7

名前と識別子

• パブケム・シド: 528767079
• カノニカル・スマイル: CNC(=NC)NCCCC(C(=O)O)N
• IUPAC Name: (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid
• InChIKey: HVPFXCBJHIIJGS-LURJTMIESA-N
• INCHI: 1S/C8H18N4O2/c1-10-8(11-2)12-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H,13,14)(H2,10,11,12)/t6-/m0/s1
• 異性体SMILES: CNC(=NC)NCCC[C@@H](C(=O)O)N
• 分子量: 202.25
• Reaxy-Rn: 4134786
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4134786&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 分類 Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Arginine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 分類: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Arginine and derivatives
• Alternative Parents: L-alpha-amino acids Fatty acids and conjugates Guanidines Amino acids Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Carboximidamides Organopnictogen compounds Organic oxides Monoalkylamines Imines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Arginine or derivatives - Alpha-amino acid - L-alpha-amino acid - Fatty acid - Guanidine - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Amine - Primary amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Primary aliphatic amine - Imine - Organic oxygen compound - Carbonyl group - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
• 説明: This compound belongs to the class of organic compounds known as arginine and derivatives. These are compounds containing arginine or a derivative thereof resulting from reaction of arginine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: guanidines - non-proteinogenic L-alpha-amino acid - L-arginine derivative - dimethylarginine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

化学的性質と物理的性質

• DMSO（mg / mL） 最大溶解度: 40
• DMSO（mM） 最大溶解度: 197.775030902349
• 水（mg / mL） 最大溶解度: 40
• 水（mM） 最大溶解度: 197.775030902349
• 分子量: 202.250 g/mol
• XLogP3: -3.700
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 202.143 Da
• Monoisotopic Mass: 202.143 Da
• Topological Polar Surface Area: 99.700 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 206.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

参考文献

1. SunHongzheng , HanLongsen , GuoYueshuai , AnHuiqing , WangBing , ZhangXiangzheng , LiJiashuo , JiangYingtong , WangYue , SunGuangyi , ZhuShuai , TangShoubin , GeJuan , ChenMinjian , GuoXuejiang , WangQiang.  (2024)  The global phosphorylation landscape of mouse oocytes during meiotic maturation.  EMBO JOURNAL,      [PMID:39256562] [10.1038/s44318-024-00222-1]