Seconeolitsine - ≥95% , CAS No.2650074-56-7

CAS: 2650074-56-7 Cat. No.: S650209 分子式: C₁₉H₁₇NO₄ 分子量: 323.34

GRADE & PURITY ≥95%

Storage

Store at 2-8°C

Shipped In

Wet ice

概要

Seconeolitsine, an antibiotic , and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC 50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics

In Vitro

Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC 50 value of 17 μM and the inhibition of TopA is enhanced by preincubation of the enzyme with the alkaloid. Seconeolitsine shows great inhibition of S.pneumoniae growth with MIC 50 values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition of S. pneumoniae growth with MIC 50 values of 8 μM for CipR42, CipR68 and CipR15. Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1. Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner. Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Topoisomerase I 17 μM (IC 50 )

Specifications

仕様と純度

≥95%

生化学的・生理学的メカニズム

Seconeolitsine, an antibiotic , and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC 50 value of 17

保管条件

Store at 2-8°C

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥95%

名前と識別子

• カノニカル・スマイル: CNCCC1=C2C=CC3=CC(OCO4)=C4C=C3C2=C5OCOC5=C1
• 分子量: 323.34

よくある質問

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2650074-56-7, the molecular formula is C19H17NO4, and the molecular weight is 323.34 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.