Seladelpar sodium salt - ≥98% , CAS No.S659166

CAS: S659166 Cat. No.: S659166 分子式: C₂₁H₂₂F₃NaO₅S 分子量: 466.45

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

概要

Seladelpar sodium salt (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC 50 of 2 nM, showing more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively.

Appearance:Solid

IC50& Target:PPAR-δ 2 nM (EC 50 )

In Vitro:MBX-8025 is an orally active, potent (EC 50 =2 nM), and specific (750-fold and 2500-fold compared with PPARα or PPARγ receptors, respectively) PPARδ agonist being developed as a lipid-altering agent [2]. MCE has not independently confirmed the accura

In Vivo:In atherogenic diet-fed Wt mice, administration of Seladelpar sodium salt reduces body weight by ~18% (P<0.05). In contrast, Seladelpar sodium salt produces minimal effect on body weight in atherogenic diet-fed foz/foz mice. Seladelpar sodium salt lowers

Biological Activity:Seladelpar sodium salt (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC 50 of 2 nM, showing more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively.

Specifications

仕様と純度

≥98%

保管条件

Store at 2-8°C,Desiccated

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

• カノニカル・スマイル: O=C(O[Na])COC1=CC=C(SC[C@H](OCC)COC2=CC=C(C(F)(F)F)C=C2)C=C1C
• 分子量: 466.45

化学的性質と物理的性質

• 溶解度: DMSO : 50 mg/mL (107.19 mM; Need ultrasonic)