SEN177 - 10mM in DMSO , CAS No.2117405-13-5

CAS: 2117405-13-5 Cat. No.: S655452 分子式: C₁₈H₁₉FN₆ 分子量: 338.38 EC番号: 821-054-9 PubChem CID: 91618245

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a K i of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates. SEN177 has the potential for Huntington’s disease research.

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a K i of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligo

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

異性体SMILES

CN1C=NN=C1C2CCN(CC2)C3=C(C=CC=N3)C4=CN=C(C=C4)F

代替CAS番号

2117405-13-5

PubChem CID

91618245

分子量

338.38

関連ターゲット（人間）

QPCT Tchem Glutaminyl-peptide cyclotransferase (1 Activities)

Discover Target: QPCT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)