SI-109 - ≥99% , CAS No.2429877-30-3

CAS: 2429877-30-3 Cat. No.: S647472 分子式: C₄₀H₄₄F₂N₇O₉P 分子量: 835.79

GRADE & PURITY ≥99%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

概要

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36

In Vitro

SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC 50 =3 μM). SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:STAT3 9 nM (Ki)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 de

保管条件

Store at -20°C,Argon charged

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

• 分子量: 835.79

化学的性質と物理的性質

• 溶解度: DMSO : 150 mg/mL (179.47 mM; Need ultrasonic)