SJB2-043 - Moligand™, 2mM in DMSO , Inhibitor of ubiquitin specific peptidase 1, CAS No.63388-44-3, Inhibitor of ubiquitin specific peptidase 1

CAS: 63388-44-3 Cat. No.: S425213 分子式: C₁₇H₉NO₃ 分子量: 275.26 PubChem CID: 509070

GRADE & PURITY Moligand™, 2mM in DMSO

Synonyms

AC-36369 | AKOS027254768 | 2-phenyl-naphtho[2,3-d]oxazole-4,9-dione | 2-PHENYLNAPHTHO[2,3-D]OXAZOLE-4,9-DIONE | MFCD26960957 | 2-phenyl-naphthoxazole-4,9-quinone | A917582 | GTPL12225 | SJB2043 | sjb2-043 | 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione | SCH

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

同義語

AC-36369 | AKOS027254768 | 2-phenyl-naphtho[2,3-d]oxazole-4,9-dione | 2-PHENYLNAPHTHO[2,3-D]OXAZOLE-4,9-DIONE | MFCD26960957 | 2-phenyl-naphthoxazole-4,9-quinone | A917582 | GTPL12225 | SJB2043 | sjb2-043 | 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione | SCH

仕様と純度

Moligand™, 2mM in DMSO

生化学的・生理学的メカニズム

IC50 Value: 0.544 uM (USP1) SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed b

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of ubiquitin specific peptidase 1

名前と識別子

パブケム・シド

528767104

カノニカル・スマイル

C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O

IUPAC Name

2-phenylbenzo[f][1,3]benzoxazole-4,9-dione

InChIKey

CMYQQADDUUDCCA-UHFFFAOYSA-N

INCHI

1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H

異性体SMILES

C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O

PubChem CID

509070

分子量

275.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 分類 Azoles
      • Subclass Oxazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 分類: Azoles
• Subclass: Oxazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenyl-1,3-oxazoles
• Alternative Parents: Naphthalenes Aryl ketones Benzene and substituted derivatives Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenyl-1,3-oxazole - Naphthalene - Aryl ketone - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Ketone - Oxacycle - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (1 Activities)

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

関連ターゲット（非人間）

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 分子量: 275.260 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 275.058 Da
• Monoisotopic Mass: 275.058 Da
• Topological Polar Surface Area: 60.200 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 443.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1