Spironolactone - Moligand™, 10mM in DMSO , Mineralocorticoid receptor antagonist, CAS No.52-01-7, Mineralocorticoid receptor antagonist

CAS: 52-01-7 Cat. No.: S409089 分子式: C₂₄H₃₂O₄S 分子量: 416.57 EC番号: 200-133-6 PubChem CID: 5833

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Spironolactone Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
In vitro

Spironolactone is a strong AR antagonist (IC50 ~ 77 nM), a weak GR antagonist (IC50 ~ 2.4 μM), and a weak PR agonist (EC50 ~ 740 nM). Spironolactone inhibits androstanolone binding in rat prostate nuclei and androstanolone specific binding in rat prostate cytosol.

In vivo

Spironolactone (1 mg/day) exerts anti-androgenic activity in rats. A single pretreatment of spironolactone (1 mg/rat) inhibits specific and saturable uptake of hormone into prostate induced by tracer dose administration of [³H]testosterone.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ANTAGONIST

作用メカニズム

Mineralocorticoid receptor antagonist

製品の性質

• ALogP: 2.9

名前と識別子

• 異性体SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
• 代替CAS番号: 52-01-7
• PubChem CID: 5833
• NSC番号: 150399
• MeSH用語: Aldactone;Aldactone A;Aquareduct;Ct, Spiro Von;duraspiron;Espironolactona Alter;Espironolactona Mundogen;Flumach;Frumikal;Jenaspiron;Novo Spiroton;Novo-Spiroton;NovoSpiroton;Practon;SC 9420;SC-9420;SC9420;Spiractin;Spiro L.U.T.;spiro von ct;Spirobeta;Spir
• 分子量: 416.57

関連ターゲット（人間）

NR3C1 Tclin Glucocorticoid receptor (1 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C2 Tclin Mineralocorticoid receptor (13 Activities)

Discover Target: NR3C2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor (1 Activities)

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 融点（°C）: 207-208 °C (lit.)

参考文献

1. Hongmei Zou, Mingxuan Zhang, Jin Chen, Stanley Aniagu, Yan Jiang, Tao Chen.  (2023)  AHR-mediated DNA damage contributes to BaP-induced cardiac malformations in zebrafish.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:37806592] [10.1016/j.scitotenv.2023.167636]

2. Fan Zhang, Yan Jiang, PinYi Chen, Huixian Chen, Tao Chen.  (2025)  Benzo(a)pyrene induces cardiac hypertrophy via the aryl hydrocarbon receptor-mediated DNA damage.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:41330102] [10.1016/j.scitotenv.2025.181061]