STAT5-IN-2 - ≥99% , CAS No.2111834-61-6

CAS: 2111834-61-6 Cat. No.: S649601 分子式: C₂₆H₂₇N₃O 分子量: 397.51 PubChem CID: 137628635

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

STAT5-IN-2 is a STAT5 inhibitor,STAT5-IN-2 has potent antileukemic effect

In Vitro

STAT5-IN-2 has EC 50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively. STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC 50 values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively. STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells). STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: KG1a and MV-4-11 cell lines Concentration: 100 nM, 10 µM, 20 µM, 30 µM, 40 µM, 50 µM Incubation Time: 48 hours Result: Inhibited cell growth in KG1a and MV-4-11 cell lines Apoptosis AnalysisCell Line: K562, KU812, KG1a and MV-4-11 cells Concentration: 10 µM Incubation Time: 48 hours Result: Significantly increased the number of apoptotic cells. Western Blot AnalysisCell Line: KG1a, MV-4-11 and KU812 cells Concentration: 10 µM Incubation Time: 24 hours Result: Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2.

Form:Solid

IC50& Target:STAT5 9 μM (EC 50 , in K562 cells) STAT5 5 μM (EC 50 , in KU812 cells )

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

カノニカル・スマイル

CC1(CCN(C2=C1C=C(C=C2)C3=CN=CC=C3)CCOC4=CC5=C(C=C4)NC=C5)C

IUPAC Name

1-[2-(1H-indol-5-yloxy)ethyl]-4,4-dimethyl-6-pyridin-3-yl-2,3-dihydroquinoline

InChIKey

BELIZDRKUICBJC-UHFFFAOYSA-N

INCHI

1S/C26H27N3O/c1-26(2)10-13-29(14-15-30-22-6-7-24-20(16-22)9-12-28-24)25-8-5-19(17-23(25)26)21-4-3-11-27-18-21/h3-9,11-12,16-18,28H,10,13-15H2,1-2H3

PubChem CID

137628635

分子量

397.51

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 分類 Quinolines and derivatives
      • Subclass Hydroquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 分類: Quinolines and derivatives
• Subclass: Hydroquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydroquinolines
• Alternative Parents: Indoles Dialkylarylamines Methylpyridines Alkyl aryl ethers Benzenoids Pyrroles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Tetrahydroquinoline - Indole or derivatives - Indole - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Methylpyridine - Alkyl aryl ether - Benzenoid - Pyridine - Heteroaromatic compound - Pyrrole - Tertiary amine - Azacycle - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as hydroquinolines. These are derivatives of quinoline in which in which at least one double bond in the quinoline moiety are reduced by adding two hydrogen atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (251.57 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2111834-61-6, the molecular formula is C26H27N3O, and the molecular weight is 397.51 g/mol. InChIKey BELIZDRKUICBJC-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.