STF-62247 - 10mM in DMSO , CAS No.315702-99-9

CAS: 315702-99-9 Cat. No.: S408141 分子式: C₁₅H₁₃N₃S 分子量: 267.35 EC番号: 631-141-1 PubChem CID: 704473

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that inducesautophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to
In vitro

In vitro, STF-62247 shows cytotoxicity and tumor growth inhibitory activity against wild-type VHL and VHL-deficient renal cell carcinoma (RCC) in a HIF-independent manner with IC50 of 16 μM and 0.625 μM, respectively. Moreover, STF-62247 also leads to cell death by increasing acidification and inducing autophagy in VHL-deficient cells. ^[1] STF-62247 specifically induces macroautophagy and enhances the fusion of autophagosome and lysosomes to form autolysosomes by interfering with Golgi-endoplasmic reticulum transport in cells that have lost VHL . ^[2] A recent study shows that induction of autophagy by STF-62247 increases sensitivity of RCC under hypoxic conditions to radiation in a VHL-dependent manner. ^[3]

In vivo

In vivo mouse model, STF-62247 at a dose of 8 mg/kg by intraperitoneal injection significantly reduces tumor growth of VHL-deficient SN12C tumor cells. ^[1]
Cell Data

cell lines：

Concentrations：', 'Concentrations': '

0 to 40 μM

Incubation Time：

Powder Purity:

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly red

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

• 異性体SMILES: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
• WGKドイツ: 2
• PubChem CID: 704473
• 分子量: 267.35

化学的性質と物理的性質

• 屈折率: 1.67
• 沸点（°C）: 444.82° C
• 融点（°C）: 174.66°C

参考文献

1. Xuehua Long, Huiqi Wang, Jianqin Yan, Yifei Li, Xue Dong, Sijia Tian, Yong Sun, Kui Luo, Bin He, Yan Liang.  (2023)  Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy.  Small,      [PMID:36932938] [10.1002/smll.202207898]

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 315702-99-9, the molecular formula is C15H13N3S, and the molecular weight is 267.35 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.