Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 110 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Sulfanilamide Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
In vitro
Sulfanilamide containing the sulfonamide functional group displays inhibitory activity for dihydropteroate synthetase partially purified from Escherichia coli which normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid acting as a coenzyme in the synthesis of purine, pyrimidine and other amino acids, exhibiting an IC 50 of 320 μM for dihydropteroate synthetasea and Km of 2.5 uM for PABA. Sulfanilamide shows IC50 of 286.8 μg/mL for recombinant S. cerevisiae strains with wild-type FOL1 genes, but the single mutation 55Trp to 55Ala or 57Pro to 57Ser within the putative active site of the fungal DHPS confers resistance to Sulfanilamide with IC50 of >800 μg/mL. Sulfanilamide moderately inhibits the growth of bacterial cells harboring plasmodium falciparum pKOS-pfPPPK-DHPS (His) with IC50 of 380 uM.
In vivo
Administration of Sulfanilamide with the dosage of 100 mg/kg/day is effective in the prevention of P. carinii infection in the immunosuppressed rat model. When the dosage of sulfaguanidine and Sulfanilamide reduced to 10 mg/kg/day, breakthrough P. carinii infection occurs in the rats.
Cell Data
cell lines：Primary HCC cell lines including 2-1318, 4-1318 and 26-1004 cells
Concentrations：
Incubation Time：
Powder Purity:≥99%
| ALogP | -0.6 |
|---|
| 異性体SMILES | C1=CC(=CC=C1N)S(=O)(=O)N |
|---|---|
| WGKドイツ | 3 |
| RTECS | WO8400000 |
| PubChem CID | 5333 |
| UN番号 | 1759 |
| 包装グループ | I |
| 分子量 | 172.21 |
| Beilstein | 511852 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| 溶解度 | Solubility (25°C) In vitro DMSO: 100 mg/mL (133.16 mM); |
|---|---|
| 融点（°C） | 164-166°C |
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