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340,000+ 研究の概要 · Triple ISO certified · COA & SDS すべての製品に適用 · 在庫品は当日出荷

SY-5609 - Moligand™, ≥98% , Inhibitor of cyclin dependent kinase 12;Inhibitor of cyclin dependent kinase 7;Inhibitor of cyclin dependent kinase 9, CAS No.2417302-07-7, Inhibitor of cyclin dependent kinase 12;Inhibitor of cyclin dependent kinase 7;Inhibitor of cyclin dependent kinase 9

CAS: 2417302-07-7 Cat. No.: S614276 分子式: C23H26F3N6OP 分子量: 490.46 PubChem CID: 146662729
COA
SY-5609 - Moligand™, ≥98% CAS No(2417302-07-7) S614276 by Aladdin Scientific
注文可能
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
CDK7-IN-3 | BDBM50583929 | 1H-Indole-6-carbonitrile, 7-(dimethylphosphinyl)-3-(2-(((3S)-6,6-dimethyl-3-piperidinyl)amino)-5-(trifluoromethyl)-4-pyrimidinyl)- | JDJOUBVVSQDIRC-AWEZNQCLSA-N | EN300-37407429 | 1H-Indole-6-carbonitrile, 7-(dimethylphosphinyl)
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
★
Size
USA
ドイツ (EU)*
Price
Qty
1mg
S614276-1mg
2 在庫あり
—

$85.90

$134.90
保存 $49.00 (36.32%)
5mg
S614276-5mg
2 在庫あり
—

$228.90

$342.90
保存 $114.00 (33.25%)
25mg
S614276-25mg
1 在庫あり
—

$771.90

$1,199.90
保存 $428.00 (35.67%)
Enter a quantity for the sizes you want to add.
Bulk / Custom
♡ ウィッシュリスト ⇅ 比較リストに入れる ⎙ Print page
SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
概要 Specifications 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造 関連ターゲット（人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 ソリューション計算機 レビュー
🧪
Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

SY-5609 (CDK7-IN-3) is a highly selective, noncovalent CDK7 inhibitor with a KD of 0.065 nM. SY-5609 shows poor inhibition on CDK2 (Ki=2600 nM), CDK9 (Ki=960 nM), CDK12 (Ki=870 nM). SY-5609 induces apoptosis in tumor cells and has antitumor activity.

Specifications

同義語
CDK7-IN-3 | BDBM50583929 | 1H-Indole-6-carbonitrile, 7-(dimethylphosphinyl)-3-(2-(((3S)-6,6-dimethyl-3-piperidinyl)amino)-5-(trifluoromethyl)-4-pyrimidinyl)- | JDJOUBVVSQDIRC-AWEZNQCLSA-N | EN300-37407429 | 1H-Indole-6-carbonitrile, 7-(dimethylphosphinyl)
仕様と純度
Moligand™, ≥98%
保管条件
Store at -20°C,Argon charged
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
等級
Moligand™
アクションタイプ
INHIBITOR
作用メカニズム
Inhibitor of cyclin dependent kinase 12;Inhibitor of cyclin dependent kinase 7;Inhibitor of cyclin dependent kinase 9
純度
≥98%
名前と識別子
パブケム・シド
528767240
カノニカル・スマイル
CC1(CCC(CN1)NC2=NC=C(C(=N2)C3=CNC4=C3C=CC(=C4P(=O)(C)C)C#N)C(F)(F)F)C
IUPAC Name
7-dimethylphosphoryl-3-[2-[[(3S)-6,6-dimethylpiperidin-3-yl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]-1H-indole-6-carbonitrile
InChIKey
JDJOUBVVSQDIRC-AWEZNQCLSA-N
INCHI
1S/C23H26F3N6OP/c1-22(2)8-7-14(10-30-22)31-21-29-12-17(23(24,25)26)18(32-21)16-11-28-19-15(16)6-5-13(9-27)20(19)34(3,4)33/h5-6,11-12,14,28,30H,7-8,10H2,1-4H3,(H,29,31,32)/t14-/m0/s1
異性体SMILES
CC1(CC[C@@H](CN1)NC2=NC=C(C(=N2)C3=CNC4=C3C=CC(=C4P(=O)(C)C)C#N)C(F)(F)F)C
代替CAS番号
2417302-07-7
PubChem CID
146662729
MeSH用語
(S)-7-(dimethylphosphoryl)-3-(2-((6,6-dimethylpiperidin- 3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-indole- 6-carbonitrile;SY-5609
分子量
490.46

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
分類Indoles and derivatives
SubclassIndoles
Intermediate Tree Nodes Not available
Direct ParentIndoles
Alternative Parents Secondary alkylarylamines  Pyrimidines and pyrimidine derivatives  Piperidines  Benzenoids  Pyrroles  Organophosphine oxides  Heteroaromatic compounds  Nitriles  Dialkylamines  Azacyclic compounds  Organopnictogen compounds  Organofluorides  Organic oxides  Hydrocarbon derivatives  Alkyl fluorides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Indole - Secondary aliphatic/aromatic amine - Benzenoid - Pyrimidine - Piperidine - Heteroaromatic compound - Pyrrole - Organophosphine oxide - Azacycle - Secondary amine - Nitrile - Secondary aliphatic amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
説明This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole.
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





関連ターゲット（人間）
CDK7 Tchem Cyclin-dependent kinase 7 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CDK9 Tchem Cyclin-dependent kinase 9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CDK12 Tchem Cyclin-dependent kinase 12 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK7 Tchem Cyclin-dependent kinase 7 (1512 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-468 (9477 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NHDF (1164 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caov-3 cell line (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC70 (557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCNE1 Tchem Cyclin-dependent kinase 2/cyclin E1 (1877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCNH Tbio Cyclin-dependent kinase 7/ cyclin H (714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCNT1 Tchem CDK9/cyclin T1 (2643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate Type日付商品
H2613426Certificate of AnalysisJun 03, 2026 S614276
H2613427Certificate of AnalysisJun 03, 2026 S614276
G2516525Certificate of AnalysisFeb 05, 2025 S614276
G2516526Certificate of AnalysisFeb 05, 2025 S614276
G2516527Certificate of AnalysisFeb 05, 2025 S614276
G2516528Certificate of AnalysisFeb 05, 2025 S614276
G2516529Certificate of AnalysisFeb 05, 2025 S614276
G2516530Certificate of AnalysisFeb 05, 2025 S614276
化学的性質と物理的性質
分子量490.500 g/mol
XLogP32.700
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass490.186 Da
Monoisotopic Mass490.186 Da
Topological Polar Surface Area106.000 Ų
Heavy Atom Count34
Formal Charge0
Complexity838.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
ソリューション計算機
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