Synta66 - 10mM in DMSO , CAS No.835904-51-3

CAS: 835904-51-3 Cat. No.: S655861 分子式: C₂₀H₁₇FN₂O₃ 分子量: 352.36 PubChem CID: 11337104

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Synta66 is an inhibitor of store-operated calcium entry channel Orai , which forms the pore of the CRAC channel, and used for the research of neurological disease .

In Vitro

Synta66 is an inhibitor of Orai, which forms the pore of the CRAC channel. Synta66 (10 μM) attenuates peak SOCE in Müller glia. Synta66 (10 μM) prevents orai channels mediating the residual SOC current in Trpc1 −/− Müller cells. Synta66 (10 μM) nearly completely blocks the Ca 2+ entry signal evoked by CaCl 2 addition, whereas it moderately reduces Ca 2+ mobilization from stores with 10% to 30% in platelet. Synta66 (10 μM) suppresses human platelet activation in plasma and whole-blood thrombus formation. Synta66 (10 μM) also inhibits murine platelet responses and thrombus formation. Synta66 (10 μM) inhibits LAD2 human mast cell line. Synta66 (10 μM) significantly inhibits FcεRI stimulated histamine and TNFα secretion, and has differential effects on FcεRI stimulated prostaglandin D2 and cytokine release in human lung mast cells (HLMCs). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Orai

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Synta66 is an inhibitor of store-operated calcium entry channel Orai , which forms the pore of the CRAC channel, and used for the research of neurological disease .

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

名前と識別子

異性体SMILES

COC1=CC(=C(C=C1)OC)C2=CC=C(C=C2)NC(=O)C3=C(C=NC=C3)F

PubChem CID

11337104

分子量

352.36

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 835904-51-3, the molecular formula is C20H17FN2O3, and the molecular weight is 352.36 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.