T-448 - ≥98% , CAS No.1597426-53-3

CAS: 1597426-53-3 Cat. No.: T646568 分子式: C₁₇H₂₀N₄OS.1/2C₄H₄O₄ 分子量: 386.50 PubChem CID: 137796965

GRADE & PURITY ≥98%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

概要

T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) , with an IC 50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons

In Vitro

T-448 enhances the levels of H3K4 methylation, increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCR. Cell Line: Primary cultured rat neurons. Concentration: 0-10 μM. Incubation Time: 1 day treatment. Result: Increased Ucp2 H3K4me2 and Ucp2 mRNA significantly.

In Vivo

T-448 has minimal impact on the LSD1-GFI1B complex and a superior hematological safety profile in mice via the generation of a compact formyl-FAD adduct. T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction . T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NR1-hypo mice . Dosage: 1, 10 mg/kg. Administration: Orally, 3 weeks. Result: Dose-dependently increased the H3K4me2 levels around Bdnf, Arc, and Fos genes in\nthe mouse hippocampus. Resulted in partial but statistically significant and dosedependent rescue effects on the rate of correct choices in NR1-hypo mice.

Form:Solid

IC50& Target:IC50: 22 nM (LSD1)

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) , with an IC 50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons.

保管条件

Store at -20°C,Argon charged

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

• カノニカル・スマイル: CC1=NN=C(S1)NC(=O)C2=CC=CC(=C2)C3CC3NC4CCC4.C(=CC(=O)O)C(=O)O
• IUPAC Name: (E)-but-2-enedioic acid;3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide
• InChIKey: BNLKYWVPJPFTMA-YWNVCFPDSA-N
• INCHI: 1S/C17H20N4OS.C4H4O4/c1-10-20-21-17(23-10)19-16(22)12-5-2-4-11(8-12)14-9-15(14)18-13-6-3-7-13;5-3(6)1-2-4(7)8/h2,4-5,8,13-15,18H,3,6-7,9H2,1H3,(H,19,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-,15+;/m1./s1
• PubChem CID: 137796965
• 分子量: 386.50

化学的性質と物理的性質

• 溶解度: DMSO : 16.67 mg/mL (43.13 mM; Need ultrasonic)

よくある質問

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1597426-53-3, the molecular formula is C17H20N4OS.1/2C4H4O4, and the molecular weight is 386.50 g/mol. InChIKey BNLKYWVPJPFTMA-YWNVCFPDSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.