TA-316 - ≥98% , CAS No.1429321-13-0

CAS: 1429321-13-0 Cat. No.: T647940 分子式: C₂₈H₂₅BrN₄O₅S₂ 分子量: 641.56 PubChem CID: 78101785

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells.

In Vitro

TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC 50 values of 0.3 and 0.65 nM, respectively. ?\nTA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers. ?\nTA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: UT-7/TPO and Ba/F3-HuMpl cells Concentration: 0.01-1000 nM Incubation Time: 4 days Result: Stimulated UT-7/TPO and Ba/F3-HuMpl cell proliferation.

Form:Solid

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

名前と識別子

カノニカル・スマイル

O=C(C1=CC=C(C(NCC2=CC=C(C(NCCO)=O)C=C2)=O)S1)N/N=C(C3=CSC(C4=CC=C(Br)C=C4)=C3O)\\C

PubChem CID

78101785

分子量

641.56

化学的性質と物理的性質

• 溶解度: DMSO : 50 mg/mL (77.94 mM; ultrasonic and warming and heat to 60°C)