TAK-653 - ≥98% , Glutamate receptor ionotropic AMPA positive allosteric modulator, CAS No.1358751-06-0, Glutamate receptor ionotropic AMPA positive allosteric modulator

CAS: 1358751-06-0 Cat. No.: T648005 分子式: C₁₉H₂₃N₃O₃S 分子量: 373.47 PubChem CID: 56655833

GRADE & PURITY ≥98%

Synonyms

TAK-653 | CHEMBL4594403 | Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide | MS-26031 | 9E3TOE5RIZ | EX-A6607 | SCHEMBL622985 | Osavampator

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

概要

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models.

Specifications

同義語

TAK-653 | CHEMBL4594403 | Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide | MS-26031 | 9E3TOE5RIZ | EX-A6607 | SCHEMBL622985 | Osavampator

仕様と純度

≥98%

生化学的・生理学的メカニズム

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats.

保管条件

Protected from light,Store at -20°C,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

POSITIVE ALLOSTERIC MODULATOR

作用メカニズム

Glutamate receptor ionotropic AMPA positive allosteric modulator

純度

≥98%

製品の性質

• ALogP: 2.7

名前と識別子

• パブケム・シド: 528767344
• カノニカル・スマイル: CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4
• IUPAC Name: 9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide
• InChIKey: PXJBHEHFVQVDDS-UHFFFAOYSA-N
• INCHI: 1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3
• 異性体SMILES: CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4
• PubChem CID: 56655833
• 分子量: 373.47

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Phenol ethers

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Phenol ethers
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenol ethers
• Alternative Parents: Phenoxy compounds Alkyl aryl ethers Imidolactams Organosulfonic acids and derivatives Tertiary amines Ketimines Propargyl-type 1,3-dipolar organic compounds Enamines Azacyclic compounds Amidines Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenoxy compound - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Imidolactam - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Ketimine - Tertiary amine - Amidine - Enamine - Ether - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic oxide - Imine - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

化学的性質と物理的性質

• 溶解度: DMSO : ≥ 12.5 mg/mL (33.47 mM)
• 感度: light & Moisture sensitive
• 分子量: 373.500 g/mol
• XLogP3: 2.700
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 373.146 Da
• Monoisotopic Mass: 373.146 Da
• Topological Polar Surface Area: 79.700 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 722.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1